Wednesday, February 27, 2008

Chronic renal failure is the standard clinical stage what?

Clinical staging criteria: 1, renal decompensation: normal glomerular filtration rate per minute 120 ml. This period of glomerular filtration rate decreased to 30-60 ml / min, Renal unit reduced by about 20% -25%. Although this loss of renal reserve capacity, but excretion of metabolites, regulating water, electrolyte and acid-base balance is fairly good, so there is no special clinical performance, muscle enzyme and blood urea nitrogen sometimes usually normal or mildly elevated. 2, azotemia: This period of glomerular filtration rate decreased to 25 ml / min, renal units declined 50% -70%, the concentration of renal dysfunction, a nocturnal enuresis or urine, varying degrees of anemia often azotemia, serum creatinine, blood urea nitrogen levels. Clinical can have fatigue, anorexia, nausea and systemic mild discomfort. If this period of neglect renal protection or body additional loads, such as severe vomiting, diarrhea, caused by insufficient blood volume, a serious kidney infection and the use of toxic drugs can be caused by the rapid decline of renal function and failure. 3, stage renal failure (pre-uremic): glomerular filtration rate decreased to every minute 10-15 ml, renal units reduced by about 70% -90%, renal severely damaged, unable to maintain Machine in vivo metabolism and water electrolyte and acid-base balance. It is impossible for the body to maintain environmental stability, resulting serum creatinine, blood urea nitrogen were significantly higher, diluted urine concentration dysfunction, acidosis, low calcium, high-phosphorus, such as high potassium imbalance performance. Anemia may significantly and gastrointestinal symptoms, such as nausea, vomiting, decreased appetite. Spirit also had neurological symptoms, such as fatigue, attention is not focused, sleepiness, and so on. 4, uremia period: glomerular filtration rate fell to a minute 10 ml to 15 ml of the following, renal units declined 90 percent over this period is advanced chronic renal failure, renal failure of the clinical symptoms become more pronounced , showed systemic multiple organ failure, such as the gastrointestinal tract, nervous system, cardiovascular, hematopoietic system, respiratory, skin and metabolic systems serious imbalance. Clinical can be in terms of nausea, vomiting, irritability, increased blood pressure, flustered, chest tightness, not supine, breathing difficulties, severe anemia, seizures, coma serious, often hyperkalemia, hyponatremia, low calcium, high - phosphorus hyperlipidemia. This period need to rely on life-sustaining dialysis. Often because of hyperkalemia, cerebral edema, pulmonary edema, heart failure and sudden death.

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