Endometrial carcinoma features

Pathological generally can be divided into diffuse, localized and three kinds of polyps. (1) diffuse: The lesions can be involved all or most endometrium. Its early endometrial hyperplasia and difficult to distinguish. However, careful inspection tumor location, there are some characteristics with the normal boundaries between endometrial identifiable, that is, cancer of the mucous membrane thickening, rough and irregular size of the polyp-like processes, and benign endometrial hyperplasia is a soft, smooth surface. Malignant polyp-like processes larger, hard, crisp, the surface of superficial ulcers, lesions Advanced ulceration and necrosis, involving the endometrium; even a small number of cases and the spread of invasive cervical or endometrial extended to the vaginal fornix. - Benign polyps, endometrial hyperplasia is confined to the cervix, mouth of the above, because the cervix endometrial hyperplasia trigger such abnormal endocrine function never react. In addition to endometrial cancer spread, developed to a certain stage to the muscularis violations, and even infiltrating the uterine serosa and transferred to the ovary, uterus beside such as the rectum and bladder. Advanced surface of tumor necrosis, ulcers, often secondary infection. (2) Limitations: Less. Limited the scope of cancer, involved only part of endometrium, and the appearance of diffuse the same. The surface of cancer of the small, and to the deep myometrial violations, resulting in increased uterine infection or necrosis Palace wall ulcer formation, or even perforation. Advanced erosion around the same or transfer. Limitations can be expressed as polyps, or in Levin flower, nodular. The former early cases, the latter more common in advanced cases, accompanied myometrial invasion. Localized tumors located in the Palace or Palace at the bottom corner. Polypoid carcinoma pretty close to ordinary benign endometrial polyps, but soft and smooth and covered in the normal mucosa benign endometrial polyps different tumor size of the polyp-like vegetation can be larger, Zhicui surface often necrosis, etc., . Sometimes polyps carcinoma small, but have all been vicious organizations, and has been for the development or deep myometrial violations. Sometimes cancer of the small number of polyps, possibly in time for all diagnostic curettage curettage, which can not be found in resection specimens of uterine cancer at the scene. Of course, there should also pay attention to when blowing up the wrong specimens for the possibility of suspicious review should be carried out proofing to prevent missing real patients. (C) polyp type of endometrial carcinoma in the uterine horn good, and common in postmenopausal.
Microscopy on four types: (1) adenocarcinoma (adenocarcinoma): about 80% to 90%. Endoscopic see increased endometrial glands, sizes, are disorders, showed back-to-back phenomenon. Sometimes a papillary epithelial to the formation of secondary intrauterine prominent gland, a gland sets gland phenomenon. Cancer cells larger, irregular, the big change was pleomorphic, deeply stained cytoplasm less split phase, with less interstitial infiltration of inflammatory cells. Poorly differentiated adenocarcinoma see glands are less structure disappeared, a solid Aiyue. International Association of Obstetrics and Gynecology (FIGO, 1970) endometrial carcinoma of three classifications: Ⅰ level (highly differentiated carcinoma): often confined to the endometrium, or occasionally single-layer papillary epithelial arranged vary, Mesenchymal less grade Ⅱ (moderate undifferentiated carcinoma): not good differentiation, the less clear outline glands, it is part of Aiyue, cells lose their polarity, common mitotic phase; Ⅲ level (low differentiation or undifferentiated carcinoma ): poor differentiation, glandular structure disappeared, it is mainly of Aiyue. (2) keratosis gland carcinoma (adenoacanthoma): also known as adeno-carcinoma acanthosis nigricans. Endoscopic adenocarcinoma characterized by a group of well-differentiated mature benign squamous epithelium, and the bridge that cell keratosis image or form keratosis beads. (3) scales adenocarcinoma (adeno-squamous carcinoma): or mixed carcinoma (mixed carcinoma), carcinoma in adenocarcinoma and squamous cell carcinoma of two components. (4) clear cell carcinomas (clear cell carcinoma): tumors showed tubular structure, and see a multitude of varying sizes under the back-to-back arrangement of the small, transparent Spike-lining cells, expressed as scarce cytoplasm, the nucleus and into the cavity , in the interstitial collagen fibers.