Hypoparathyroidism disease

This disease is due to parathyroid hormone (PTH) secretion synthesis or inadequate, No blood circulation or biological activity of PTH, or PTH not sensitive target organs, such as PTH have any effect link obstacles, clinical performance to Tetany, hypocalcemia and hyperphosphatemia and serum PTH characterized by a lower level of clinical comprehensive levy. The disease can (1) thyroid or parathyroid surgery or neck injury parathyroid radical operation or its blood supply, (2) of idiopathic may be related to autoimmune abnormality; (3) a very small number is due to genetic defects , adjacent to a target organ gland caused by abnormal receptor.
Clinical manifestations: 1. Stress increased neuromuscular disease: The feeling of numbness, tingling, thereby Tetany: thumb adduction, and other finger tight, metacarpophalangeal joint flexion, extension interphalangeal joint, wrist and elbow flexion was related midwives hand. Chvostek's levy, the levy Trousseau's positive, deep breathing test: deep breathing 3-5 minutes can be induced respiratory alkalosis caused Tetany.
2. Neuropsychiatric symptoms: The emotional instability, irritability, anxiety, depression, paranoia, orientation, memory decline.
Cataract, child dental calcification insufficiency, a tooth delay, adult teeth early shedding.
Diagnosis: 1. Idiopathic have positive family history, and acquired a low side have surgery or 131I treatment history.
2. Clinical manifestations of hand foot weak, Chvostek levy, Trousseau levy positive. Dry skin, pigmentation, hair sparse, shedding. Nail simply. Cataract. Calcification incomplete teeth, tooth quality thin, poor development of tooth enamel. Intellectual迟顿, personality change.
3. Hypocalcemia and hyperphosphatemia, normal serum alkaline phosphatase. Urinary calcium, urinary excretion of phosphorus reduction. CAMP displacement decreased urine.
4. Lower level of serum PTH. Renal tubular reabsorption of phosphorus increased phosphorus clearance rate lower.
5. X-ray examination: cerebral basal ganglia, renal calcification, bone density normal and idiopathic next to a low increase.
6. Except other reasons to be hypocalcemia of Tetany such as renal tubular acidosis, hypomagnesemia, and other respiratory alkalosis.