Prostate cancer and diseases of the differential

1. Should be differentiated from benign prostatic hyperplasia: they generally easy to identify. But in the prostate gland hyperplasia, Some regional epithelial cell morphology not typical, can be mistaken for cancer. Differences between key points are: in the acinar larger gland hyperplasia, collagen fiber layer surrounding the integrity of the double-decker high columnar epithelial nuclei in patients with prostate cancer than the small, and bottom-living cells, glands with rules, a clear nodule. 　　 2. Shrinkage of the prostate and identification: the prostate cancer often begins with the atrophy of the glands should observe the differential. Sometimes close gathered acinar atrophy, atrophy smaller cubic epithelial cells, nuclear, much like cancer. But many of these changes involved the entire shrinking lobule, the connective tissue collagen layer is complete, the matrix is not breached its own enjoying sclerosing atrophy. 　　 3. Prostate and squamous cell metaplasia or transitional phase identification: the gland often occurred in the healing of the infarcted zone, or transitional epithelium squamous cell differentiation good, no degeneration or splitting phase. Chemical and biological weapons are the most prominent features of ischemic necrosis or lack of smooth muscle fiber connective tissue matrix. 　　 4. GP: cells, can be gathered into flake. Transparent or light red staining cytoplasm, the bubbly small nucleus, much like prostate cancer, but actually macrophages. Those cells were pleomorphic, condensation nuclei, a vacuolar-shaped, small size, as rafts or clustering arrangement, and sometimes that some acinar. Differential attention should be paid to the acinar GP formed small lesions and normal relationship No change, often degeneration of amyloid precursors and multinucleated giant cells. While prostate cancer cells were low cylindrical or cubic, with clear cell wall, the dense eosinophilic cytoplasm and the nucleus than normal, staining and shape can have variability, separatism is not active. Its acinar smaller, lack of Qu tubular, with the normal form of complete loss, irregular infiltration to the matrix, connective tissue collagen layer has been non-existent. Acinar contain a small amount of secretion, but very few of the amyloid. Prostate cancer case of obvious degeneration, the organizational structure completely disappeared, there is no acinar forming tendency. 　　 5. Addition, prostate cancer and prostate should tuberculosis, prostate stones phase differential.