Scleroderma several points in the clinical

Clinical skin involvement on the basis of the scope, Systemic scleroderma will be divided into the following four types. (1) rapid onset systemic scleroderma, a symmetry hand, foot and facial skin changes tight, hardening and thickening, and involving the proximal extremities and neck, spread to the trunk, with lung, heart, gastrointestinal tract kidneys and other offal or damage. Anti-nuclear antibody positive, a small number of patients anti-centromere antibody positive. They are characterized by lesions progress fast, visceral damage appeared earlier, poor prognosis, 10-year survival rate was 40% -60%. (2) limitations of systemic scleroderma skin lesions confined to the fingers, the distal forearm and leg and face and neck, skin change for the symmetry tight, hardening and thickening, with Raynaud's phenomenon, the late, there will be the Pulmonary Hypertension and that kind latest change. Most of the patients anti-centromere antibody positive, some patients showed CREST syndrome. This type relatively good prognosis, 10 survival rates greater than 70%. (3) overlap syndrome diffuse or localized systemic scleroderma, a merger or a variety of other connective tissue diseases. (4) No-systemic scleroderma skin sclerosis less than 1% of the systemic scleroderma patients only offal hardening of the skin damage without change. For performance; ① esophageal activities barriers, expansion of the duodenum, colon bags formed ② Renault phenomenon, a wrinkle telangiectasia, obstacles and esophageal activities oliguric renal failure; ③ pulmonary hypertension associated with the above symptoms or interstitial lung disease .