The signs and symptoms of renal cell carcinoma

Primary renal cell carcinoma is a relatively rare malignancy but urology,But more common. In China, for renal cell carcinoma of the bladder cancer after the second in the urinary tract cancer, but also adult kidney is the most common malignant tumor of. Age of onset are over 40 years of age, the incidence increases with age, the median age of onset is 65 years old. Male / female incidence rate is about 2 / 1. In recent years the incidence of renal cell carcinoma early age trend, we can see that the minimum age of onset, 1 case 7-year-old boy. The incidence of renal cell carcinoma clinical increased steadily in recent years, and the proportion of the early lesions also increased. Some people think that this is because as health care and imaging technology develops, more tumors were detected by the results, but the real incidence of cancer has not increased significantly. Under normal circumstances, according to clinical data in the diagnosis of renal cell carcinoma is not difficult, but false-positive or false-negative diagnosis occurred from time to time, comprehensive and careful analysis is the basis for accurate diagnosis. First, symptoms and signs In peritoneal kidney after abdominal viscera of the muscle and back by enveloping, it is often the lack of kidney tumors early clinical manifestations, from the traditional call hematuria, abdominal pain and a mass of the "triple renal cell carcinoma levy" are lesions development of the later symptoms. However, noteworthy is that renal cell carcinoma may be a variety of "extra - renal manifestations," with other clinical easily confused with systemic diseases, but these symptoms often lead to patients and attending to the causes. In addition, since the symptoms of tumor metastasis to the treatment of renal cell carcinoma was found to be the case is not uncommon. 1. Hematuria: kidney occurred through contact with the outside world urine, hematuria renal cell carcinoma is the most common clinical symptoms of cancer of the renal pelvis or violations of renal calyceal mucosa caused. About 40 to 60 or so patients in varying degrees of hematuria, usually painless intermittently throughout gross hematuria, blood clots sometimes strip, the type of the ureter. Gore blocked ureter, can cause renal colic. 2. Pain: pain caused by multiple renal cell carcinoma occurred in the waist, the nature of, the incidence is about 20. The reason is due to tumor growth distraction because of kidney capsule, but also because of violations of the surrounding organs or tumors caused by the psoas, the latter often heavier and lasting pain. Hematuria caused serious form clots can occur when ureteral obstruction renal colic. 3. Abdominal mass: renal cell carcinoma patients who have abdominal mass performance of about 20, lanky body to more easily arise in the upper abdominal Legong, with the upper and lower respiratory movement and mobile. Checks may be touched by the tumor itself, but also may have been the passage of renal tumors under extremely. If mass fixed and the kidney tumor has been violated around the organ structure, this patient's tumor resection difficulties, poor prognosis. 4. Kidney, performance: In addition to the kidney is an important organ of metabolic, endocrine organ or a, in normal circumstances can be synthesized and secreted prostaglandin E1, 25 - dihydroxy vitamin D3, renin and erythropoietin, kidney can secretion much higher than normal levels of these hormones, parathyroid hormone secretion at the same time also like factor, glucagon, and insulin to human chorionic gonadotropin, and other substances, resulting a wide variety of renal cell carcinoma, renal systemic symptoms about 20. In addition to these symptoms of high blood calcium, the other it is difficult to eliminate conventional treatment, but in the primary tumor resection, many indices can be back to normal. (1) ESR Express: renal cell carcinoma patients to the reasons for the fast ESR is not clear, the incidence rate in the 50 or so. Norway's University of Oslo, one pair of 236 cases of renal cell carcinoma patients in the retrospective study found that 70.3 patients ESR fast performance, even in the renal cell carcinoma was diagnosed before six years, there has been, therefore propose that the continued ESR patients should be done soon renal ultrasonography to except kidney tumor. (2) fever: in renal cell carcinoma patients are more common, the incidence was about 20. Recent studies have found that 25 of the primary tumor could Ectopic secretion of interleukin-6, this ectopic secretion of interleukin-6 may be related to the fever. (3) hypertension: About 20 of kidney cancer patients have high blood pressure, but recent epidemiological survey showed that the treatment of hypertension and hypertension drugs and bone cancer incidence, therefore, only when the returned to normal after resection of renal cell carcinoma can only confirm hypertension renal cell carcinoma is caused by. Excessive renin secretion, moving within the tumor - arteriovenous fistula, renal vascular tumor suppression may be caused hypertension causes. (4) high blood calcium: It is not very clear situation, the incidence of about 10. The tumors may be related to a similar parathyroid hormone-related protein peptide related. After returning to normal tumor resection, tumor recurrence or metastasis may be reconsidered after the increase. Sometimes from high blood calcium may also cause cancer metastasis to the bone. (5) Erythrocytosis: Specific reasons unclear, and may direct the secretion of tumor or tumor erythropoietin oppression caused normal renal tissue ischemia, stimulating the secretion of erythropoietin. (6) abnormal liver function: not due to tumor metastasis to the liver caused, also known as Staufer syndrome, patients at the same time leukopenia, fever and partial necrosis of the liver. After renal tumor resection of liver function returned to normal, or is likely to have metastases. A few cases may also be associated with cholestasis jaundice. (7) Other: anemia, weight loss, elevated serum alkaline phosphatase, amyloidosis and neuropathy, and so may occur in the renal cell carcinoma patients. 5. Varicocele: Features for the supine position will not disappear, as renal vein or inferior vena cava hinder tumor thrombus within the spermatic vein returning blood from within. 6. Metastases: renal cell carcinoma metastasis often occurred earlier, when the primary can be a very hour shift, and changing the location of the transfer, almost any site found in the human body. About 20-35 cases of renal cell carcinoma in patients attending the transfer has already happened, and about 6-15 patients is a result of tumor metastasis to the symptoms and treatment. In addition to lung, liver, brain, bones and other common sites of tumor metastasis, renal cell carcinoma often transferred to other rare sites, such as the common bile duct cavity, mediastinum, a thumb, vagina, choroid, and the orbital and other external auditory canal. Evidently, appear in any part of the body of abnormal, especially those of unknown origin, should think of the possibility of renal cell carcinoma metastasis. 7. Associated cancer: Di Silverio had been reported 17 cases of primary renal cell carcinoma patients, the prevalence of steroid hormones target organ of primary tumors, including breast cancer 10 cases, endometrial cancer four cases and ovarian cancer three cases . Although it can not be the result of hormone-dependent renal cell carcinoma, renal cell carcinoma and to a certain extent suggested that the link between these tumor is estrogen. 8. Accidental discovery: Entering the 1980s, with the imaging technology's rapid development, more and more routine physical examination in renal cancer or other diseases inspection was "accidentally" discovered, the general view of the current renal cell carcinoma patients 30 above. Jayson, and other reports in 131 cases of renal cell carcinoma, 61 belong to no subjective symptoms of sporadic cancer. Author units 1991-1995 treated 217 cases of renal cell carcinoma, 103 cases of sporadic cancer.