Uremic state have any effect on metabolism

Renal failure, Waste accumulation in vivo metabolism of many physical systems can be involved. Cell function decline in the activity of reduced hydropower imbalance, renal failure on the metabolic effects of the following main features: (1) glucose metabolism disorders mildly elevated blood glucose in patients with uremia, which increased with the pathogenesis of different diabetes, diabetes is absolute or relative insulin secretion inadequate, and high blood sugar in patients with uremia mainly cells to insulin sensitivity lower. Normal oral certain amount of glucose, serum insulin has correspondingly increased if diabetic patients, this increased more significantly, the need for this more than normal cells use insulin to glucose. According to reports, uremic patients endogenous insulin secretion of normal, the uptake of exogenous insulin in the body to maintain a level higher than normal, due to insulin in the blood in uremic patients can be maintained longer, chronic diabetic patients the event of uremia, insulin dosage can be reduced. (2) protein metabolism obstacles protein metabolism produce nitrogenous waste, as Pai not see in vitro, in vivo accumulation, BUN increased. Therefore, in the treatment of uremia, generally restricting protein intake, patients with malnutrition, long-term hemodialysis patients, protein intake restrictions can be relaxed slightly more, uremia amino acids in serum of patients with abnormal, some human serum concentrations of certain amino acids could be higher than the normal 2 to 3 times. On the other hand, essential amino acid serum levels may be lower than normal, the lack of essential amino acids for autologous tissue reconstruction could be greatly affected. (3) abnormal fat metabolism of fat metabolism in uremia yet to be affected too much research, known most dialysis patients, serum triglyceride and free fatty acids increased the level of blood cholesterol and phospholipid normal.