Friday, February 15, 2008

Vigilant drug-induced gastritis

Gastritis, is a common disease of the digestive system. Gastritis due to the impact of food digestion and absorption, and therefore very great harm to the health of patients. According to the experts confirmed that many of the drugs can produce different levels of gastric mucosal injury. Common drugs for the clinical manifestations of gastritis, abdominal discomfort, pain, heartburn flu, loss of appetite, nausea, vomiting, pantothenic acid water, there are also serious hematemesis, hematochezia, hemorrhagic shock, or even gastrointestinal perforation with peritonitis, If not promptly treated, may endanger the patient's life.
The mechanism of drug-induced gastritis, depending on the drug to another. Taisong such as security, indomethacin can inhibit gastric secretion, reduce its protection of the gastric mucosa, resulting in gastric mucosal injury, inflammation. Long-term doses hormones such as prednisone and other drugs, can reduce the secretion of gastric glands, gastric mucosal barrier weaken the protective effect of the gastric acid and pepsin secretion increased prevent gastric epithelial cell regeneration, thus leading to gastritis, ulcers , and even bleeding, perforation. Commonly used drugs such as aspirin, can undermine the lipoprotein gastric epithelial cell layer, to be gastric pepsin digestion, causing erosion and bleeding. Gastritis drug use and the occurrence of drug dose and the method of the medication, because of time incidence vary, and in some cases a few hours after the medication developed symptoms, while others are there many times after medication.
In order to prevent the occurrence of gastritis drug, the patient should be cautiously uses a pungent drugs, such as aspirin antipyretic analgesics, such as aspirin compound; antirheumatic drug-Taisong, ibuprofen, indomethacin ; the anti-inflammatory antibacterial sulfa drugs, erythromycin, tetracycline, furazolidone reserpine, as well as cardiovascular category, such as digitalis category. In patients with medication should be followed instructions, taking time by volume, not to arbitrarily increase the medication dose or extended time. Been suffering from gastritis, gastric and duodenal ulcers in patients with the disease, they should avoid taking the drug could stimulate stomach, increased illness and prevent relapse. If required because of illness, should also stimulate small selection of drugs, and the meal taken to reduce the stimulation drugs on the gastric mucosa. For more than long-term drug use should be at the same time serving Weishuping, aluminum hydroxide gel, and other drugs to protect the gastric mucosa. Once a drug gastritis, physicians should be requested early diagnosis and treatment, effective treatment to avoid losing time.

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