What causes scleroderma

Scleroderma is also known as systemic sclerosis, A clinical limitations, or to diffuse thickening of the skin characterized by fibrosis and can affect heart, lung, kidney and digestive tract and other organs of connective tissue disease. If both involved skin lesions, transgression and offal, called systemic scleroderma; if lesions confined to the skin without damaging internal organs, known as the limitations of scleroderma. Systemic scleroderma distribution throughout the world, but not around the high morbidity. The United States in 1971 survey found that the number of new systemic scleroderma patients 2.7/100 million people, male female patients about the 3-4 times. The incidence of any age can be, common to 30 to 50 years of age, the peak incidence for women of childbearing age groups, children relatively rare, while children and limitations are more middle-aged disease. The reasons for the cause scleroderma, is not yet entirely clear. A number of risk factors may be relevant, including genetic and environmental factors, such as foundation. It has been reported in patients with systemic scleroderma relatives, at the same time suffering from the disease or another connective tissue diseases, such as systemic lupus erythematosus; recent study found that HLA-II (human leukocyte antigen - Ⅱ) gene and systemic scleroderma immune genetic and therefore that is the genetic basis of risk factors. The view was expressed that the disease in high incidence of women, especially women of childbearing age, the incidence of sex hormones may be useful. Now clearly some chemicals and drugs, can cause scleroderma-like skin changes addition, the incidence of systemic scleroderma in coal, gold and silica dust contact with the higher incidence rate in the crowd, which are systemic scleroderma suggested that the cause of environmental factors plays an important role. Have information to fully support a wide range of systemic scleroderma immune abnormalities. The study found that in recent years, suggesting that the virus antigen and self-antigens cross-reaction to the occurrence of this disease, it may be related to infection. So now that the disease may be repeated in the genetic basis of chronic infection leading to autoimmune disease, the last of the connective tissue metabolism and cause vascular anomalies.