Chlamydia pneumonia

Overview Chlamydia pneumoniae (chlamydia pneumoniae) as a newly discovered chlamydia, the main cause respiratory and lung infections. 1986 Grayeton other students in acute respiratory infection, it was found that a Chlamydia After respiratory diseases in adults were found, then named Chlamydia psittaci TWAR - TW strains After the study shows that the chlamydia as a new species and named Chlamydia pneumoniae. Pathology Disease Chlamydia pneumoniae and Chlamydia trachomatis and Chlamydia psittaci is the same antigen specificity, and other specific antigen in serum characteristics are different. Usually DNA hybridization test and restrictive endonuclease analysis confirmed as different from trachoma and the third Chlamydia psittaci Chlamydia. Mild clinical manifestations can be no obvious symptoms. Young people often voice hoarse, dry cough and sometimes fever, throat tightness, and other pharyngitis, laryngitis, sinusitis, otitis media and bronchitis symptoms and sustainable few weeks ago, the outbreak of atypical pneumonia is usually light, Chlamydia pneumoniae infection and the clinical performance very similar, and may be accompanied by pulmonary nodules performance of lupus, thyroiditis, encephalitis and Guillain-Barre syndrome. Adults over the more serious pneumonia, especially the elderly often must be hospitalized for respiratory support and treatment. By the author of a serological survey found that Chlamydia pneumoniae infection and a correlation between coronary heart disease, but much further. In addition, Chlamydia pneumoniae infection asthma mechanism is also among the discussions. Chlamydia pneumoniae pneumonia in the lungs of regular X-ray examination showed lung Asian invasion of a small flake favorite, extensive real change only found in a serious condition were. Most patients with blood leukocytes in the normal range. A diagnosis. Chlamydia trachomatis pneumonia in 1975 there was a report of neonatal pneumonia chlamydia, secondary to his inclusion after purulent card. This disease from infected mother to the eye infection can be transmitted by the nasolacrimal duct into respiratory tract. Symptoms at birth after 12 weeks of two-emergence of slow onset, we may have upper respiratory tract infections, no fever or more than occasional low heat, then cough and shortness of breath, often small suction Rale wet or twist pronunciation, rare sexual wheezing breath. Bilateral chest revealed extensive interstitial and alveolar infiltration, inflatable excessive levy more common and occasionally lobar consolidation. Peripheral blood leukocyte count normal, eosinophils increased. From the nose throat must then take a biopsy of the epithelial cells. Also available direct fluorescent antibody test (DFA), enzyme immunoassay test (EIA) detection of Chlamydia trachomatis nasopharyngeal specimens antigen. Serological examination of specific antibody diagnostic criteria for the double-serum antibody titers increased more than four-fold, or IgM "1:32, IgG "Biology. Applications can also direct PCR detection of chlamydia DNA. 2. Chlamydia psittaci pneumonia from exposure to poultry or infected in guano, poultry breeding, selling and slaughtering of the diseases. Human-to-human infection rare. Since pathogens secretions and faeces ingested, can be infected long time. Chlamydia psittaci enter the body through the respiratory tract, the monocyte breeding and release toxins. Disseminated by blood to the lungs and body tissue, lung timbre and perivascular cell infiltration, and hilar lymphadenopathy. 6 ~ 14 days incubation period, the incidence of influenza-like symptoms were often 38 ~ 40.5 ° C fever, cough, initially a dry cough, After a phlegm, dyspnea or light or heavy. A relative bradycardia, muscle pain, chest pain, loss of appetite, nausea and sometimes vomiting. Such as sepsis, which are symptoms of central nervous system infection or myocarditis performance, occasionally jaundice. More liver, spleen, and the need typhoid fever, sepsis differential. Chest X-ray examination, from the periphery to the hilum, especially downward lung middle ground glass-like a little shadow-like video. Peripheral blood leukocyte count to normal ESR illness early in slightly faster. Effusions alveolar phagocytic cells can be found chlamydia see inclusion. Children with mild fever 3 ~ 7 days gradual regression. China syndrome 8 ~ ~ 14, 20 ~ 25 days of severe cooling. After the disease weakened immunity may relapse, it is reported recurrence rate was 21%, then 10% rate. 3. Chlamydia pneumoniae pneumonia with the nonspecific clinical manifestations, and Mycoplasma pneumonia similar. Alleviate the onset, longer duration, generally mild symptoms, often accompanied pharynx, sinusitis laryngitis and its characteristics. Upper respiratory tract infection symptoms dissipated, there are dry Rale such bronchitis, pneumonia performance. Coughing symptoms for more than three weeks. WBC normal, non-specific chest, most of the lower lobe of unilateral invasion, segmental performance of pneumonia, In severe cases showed extensive bilateral pneumonia. Inspection and pathogens Chlamydia trachomatis pneumonia, from the trachea or nasopharyngeal draw compounds cell culture, chlamydia pneumoniae positive. Or a combination of fluorescent Chlamydia pneumoniae-specific monoclonal antibodies to identify the cell culture Chlamydia pneumoniae. PCR detection of Chlamydia pneumoniae DNA is more sensitive than culture, but with throat samples, it is not ideal enough. Serological testing as Chlamydia pneumoniae-specific antibodies. Microimmunofluorescence (MIF) test Chlamydia pneumoniae is the most sensitive. Specific IgM antibody 1:16 or ≥ ≥ Chlamydia IgM antibody titers, or more than four times higher have diagnostic value.