Diffuse mesothelioma

Overview of pleural mesothelioma have a better prognosis of benign fibrous mesothelioma and diffuse malignant pleural mesothelioma. The latter is considered to be the worst prognosis chest tumor, yet no effective treatment measures. Cause all types of asbestos fibers, and almost all of the pathogenesis of mesothelioma, But fiber self-sufficiency is not the same as dangerous, the most dangerous is to contact the Qingshiling Mian, the danger is the smallest touch asbestos. First contact with asbestos-induced disease in incubation period is generally 20 ~ 40, The incidence of mesothelioma and exposure to asbestos and the time is proportional to the severity. Mao atmosphere as zeolite content increase, people inhaling those silicate zeolite powder, can cause mesothelioma. It is also reported that after radiation exposure caused pleural mesothelioma cases, from the radiation exposure of pleural mesothelioma was found to be suffering from the time of 7 ~ 36, the average 16. Nitrosamines, fiberglass, hydrocyanic acid, oxidation thorium Beryllium and other pulmonary diseases (such as tuberculosis and chemical substances and lipid aspiration pneumonia), may also lead to pleural mesothelioma. Pathological changes in malignant mesothelioma early, be visible to the naked eye at normal or opaque visceral or parietal pleura on the many white or gray particles and thin plate or nodules, Along with the development of cancer, pleural thickening increasing the surface, covered with nodules, tumor extended to the Quartet, continuous tracts, it pits lung cyst narrow the scope enable involvement lateral chest wall collapse. Late in the tumor can affect the diaphragm, intercostal muscle, mediastinal and pericardial and pleural opposite. Autopsy patients found to be 50% hematogenous metastasis, but clinical rarely mentions. Malignant mesothelioma have two types of pathological anatomy : ① single fiber pleural mesothelioma. From the visceral pleura growth, flat or pedicle-tumor arising from the clinical symptoms as they expand, Squeeze intrathoracic structures to make them shift, if early diagnosis and can be used for surgical treatment. ② widespread proliferation of mesothelioma. This type of violations lobe, infiltrating the diaphragm, intercostal muscle, and through the involvement of mediastinal pleura pericardium and great vessels. Malignant mesothelioma microscope seen any of the characteristics of that individual in the tumor nodule or the naked eye appearance of the same tumor nodules, Obviously there are various different composition. Cheung malignant skin tumor in a credit - epithelial type, fiber (interstitial) and mixed three. E - epithelial tumor cells with different structures, such as papillary, tubular, possession of papillary, herpes successful flake. Polygon epithelial cells have many long and thin branches of the surface microvilli, desmosomes, Stretch bundles of filaments and cell cavity (Figure 2). Fiber cells similar spindle, equality configuration, a slender egg shape or form the nucleus, nucleolus well developed (Figure 3). Mixed-both epithelial and fiber-both organizational structure. From a block tumor biopsy, from various parts of the specimens from the affliction, the more like mixed. Figure 2 - epithelial malignant pleural mesothelioma (left), and malignant pleural mesothelial cancer (right) Figure 3 malignant mesothelioma fiber-male 81-year-old , collagen bundles and various atypical cells