Familial and sporadic ankylosing spondylitis disease phenotype similar

Dutch researchers found that family history of ankylosing spondylitis (AS) patients with the disease phenotype and sporadic ankylosing spondylitis basically the same. Amsterdam Jan van Breemen Institute and the Vrije Universiteit Medical Center Division of Rheumatology staff both AS phenotypic differences were assessed. A total of 165 patients participated in this study, which called familial 55, called 110 distributed surname. AS patients with familial generation within the definition of immediate family members with AS, distributed generation of AS patients within the immediate family did not AS, and in all age and gender AS patients with familial match. Dr. Marcel van der Paardt and his colleagues found that the incidence of these patients regardless of age, diagnosis, extent of involvement of the peripheral joints, as well as acute inflammation of the eye pigment to what extent these two AS phenotypic differences are not significant. The researchers concluded that, in view of these two groups of patients showed that the two AS phenotypic expression and does not reflect the potential of genetic differences.