Treatment of chronic pyelonephritis principle

Due to chronic pyelonephritis repeated attack, kidney inflammation and to repair the turn, connective tissue proliferation and scar formation, making poor local blood supply, antibiotics difficult to access lesions local drainage impeded, difficult to remove bacteria, inflammation refractory , impaired renal tissue repair difficult. And the resumption of kidney damage, from repeated infection is also an important factor. Thus the treatment of chronic pyelonephritis focus on the eradication of bacteria as soon as possible, to resume as soon as possible kidney damage. At the same time actively looking for risk factors, and has to do, is the prerequisite for an effective antibiotic therapy. Such as surgical treatment of benign prostatic hypertrophy, urinary tract obstruction can be lifted, can be a more effective treatment pyelonephritis. On the principles of antibiotic therapy:
(1) the choice of antibiotics regular urine culture and colony counting, and taking into account the results of drug sensitivity tests to choose the most sensitive to antibiotics. As more stubborn bacteria to antibiotics combined 2-3 better.
(2) The course of treatment for chronic pyelonephritis is the key to success, not enough drug treatment, even though the treatment effective, often fails to completely wipe out the bacteria, resistant trained at the same time, bacteria have a break once the appropriate conditions, relapsed, and the illness was deferred. Therefore, acute chronic pyelonephritis, according to the treatment of acute pyelonephritis principle medication, the course of not less than four weeks. When clinical symptoms were controlled, it can stop observation, the general urine routine monthly inspection, and a urine culture, a total of six months. If there are still bacteria in urine, can be long-term low-dose antibacterial treatment, the specific method is as follows: every night before sleep after voiding a single oral dose of antibiotics, the dose daily dose 1/3-1/2. Antimicrobial 3-4 choice for a group of recycling, so that side effects can be minimized, but also the prevention of the formation of drug resistance, but also achieve better inhibitory effect. Such as the choice of co-trimoxazole, Amoxycillin, such as cephalosporin Ⅳ. Course there is still no decision can be four months, six months or even one year.