What is seronegative spondyloarthropathy

Seronegative spondyloarthropathy is serum rheumatoid factor (RF) negative, with; similar characteristics of interconnected multi-system inflammatory disease. Seronegative joint disease packets; including ankylosing spondylitis, Rett syndrome, enteropathy arthritis, psoriatic arthritis, reactive arthritis, youth chronic arthritis (ankylosing spondylitis subtype), as well as a ONGOING group classification, such as the spondylarthropathies. Some of this is attributable to a class of diseases, because they are in clinical many common characteristics: ① serum rheumatoid factor negative, in fact positive率同normal population, generally do not exceed: 5%. ② a family aggregation. ③ and HLA-B. , Antigen have varying degrees of correlation, with ankylosing spondylitis and Rett syndrome is particularly close. ④ spine can be affected, in varying degrees of sacroiliac arthritis, can also affect peripheral joints, mostly lower limb joints than upper limb joints, and was asymmetric. ⑤ spondyloarthropathy between various clinical often overlap, there can be separate or overlapping exist, such as rash and nail psoriasis lesions, ophthalmia, stomatitis, oral, intestinal and genital ulcers, urethritis, prostate inflammation, and thrombosis of erythema nodosum of phlebitis. ⑥ pathological changes on the surrounding tendon-bone and ligament attachment to the site, rather than in the synovial membrane; may also occur in the eyes, aortic valve, pulmonary and skin. It is precisely because of these diseases, there are many commonalities, unlike serum rheumatoid factor positive diseases such as rheumatoid arthritis, clinical presented seronegative spondyloarthropathy Name this.