Thursday, June 19, 2008

The pathogenesis of disk edema

Intracranial hypertension is generally believed that the cerebrospinal fluid through subarachnoid to the optic nerve conduction intrathecal, the optic nerve caused the hypertension, and destroyed the normal optic nerve axoplasmic transport on which the intraocular pressure and the pressure within the optic nerve between the pressure gradient, the optic nerve sheath Omentum cavity under high pressure, may also lead to the deformation and displacement sieve, sieve also caused the pressure on the optic nerve axon. In addition, the optic nerve axoplasmic transport occurred in the sieve block, causing the axons sieve before the swelling and expansion of the optic disc edema. That is not the main reason for cell edema (swelling or organization glial gap accumulation), but because of the speed of axoplasmic flow two-phase occurred in the sieve block of axoplasmic accumulation of particles produced and compact size-so that the shaft Cable itself swelling. Only a edema in the disk around the optic nerve and intracranial meningeal cavity structure of the existence of a clear, if these meningeal tumor cavity adhesion or obstruction, blocking side will not happen optic disc edema. In the event of disk edema, such as the optic nerve has been shrinking, no edema nerve fibers do not exist in the optic disc swelling, as there are still remnants of a nerve fiber optic disc edema can occur. Unilateral optic disc edema and congenital or acquired partial optic nerve sheath abnormalities may be related to common diseases such as due to local inflammation, ischemic optic neuropathy or orbital was pressure. Also the so-called unilateral, bilateral optic disc is edema of the asymmetry it, simple negligence fundus easy to check.

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